Acta Veterinaria 22. (1972)
1. szám - MOSSALAM, I. - ATALLAH, O. A. - HOSNEY, Z.: Experimental studies on visceral larva migrans of Toxocara canis in laboratory animals
MOSSALXM ut al. Results Mouse : Liver examined 30 days after the infection showed larvae surrounded by fibroblasts and eosinophils (Fig. 1). Kupffer cells and endothelial cells lining the hepatic sinusoids were swollen. Rat : The livers examined on the 10th day of the infection were congested and showed focal hepatic necrosis and interstitial aggregations of eosinophils. Guinea-pig : Larvae were found among hepatic cells 10, 20, 30 and 40 days after the infection. Lymphocytic infiltration with fibroblastic proliferation was present in the portal tracts of the liver, which was congested and exhibited numerous necrotic foci after 10, 20 and 30 days of the infection. Some larvae failed to induce inflammation, but others were surrounded by necrotic debris, fibroblasts and eosinophils from 10—20 days after the infection. Yet other larvae were enclosed in a thick fibrous tissue capsule (Fig. 2) infiltrated with eosinophils. From day 30 after the infection, the cytoplasm of most hepatic cells was vacuolar or hydropic and showed focal necrosis, but there were also signs of repair and regeneration. Reticulo-endothelial cells were swollen. Chicken: Larvae were mostly seen subcapsularly among the hepatic cells and inside the sinusoids, both with and without surrounding inflammation, after 10, 20 and 30 days of the infection (Fig. 3). The reaction around the larvae on the 10th day consisted of necrotic debris, eosinophils and lymphocytes (Fig. 4). Numerous nodular interstitial lymphocytic infiltrations together with a few eosinophils were seen among the hepatic cells. The Kupffer cells and endothelial cell lining of hepatic sinusoids were swollen. Some bile ducts revealed a Fig. 1. Larva of Toxocara canis surrounded by fibroblasts and eosinophils in the liver of a mouse 30 days after infection. x!50 Fig. 2. Larvae surrounded with a thick fibrous capsule in the liver of a guinea-pig 40 days after infection. X 200 Acta Veterinaria Academiae Scientiarum Hungaricae 22, 1972